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Lile PicDr. Joshua Lile
Departments of Psychiatry and Behavioral Science
College of Medicine
Department of Psychology
College of Arts & Sciences
University of Kentucky
465 E High Street, Suite 204B
Lexington, KY 40507

Dr. Joshua Lile received his Ph.D. in Pharmacology from Wake Forest University in 2002. He is currently a Tenured Associate Professor in the Departments of Behavioral Science, Psychiatry and Psychology at the University of Kentucky. His research is focused on the neurobiological and environmental bases of drug use disorders and the development of interventions. A primary research interest is in cannabis-use disorder. One ongoing clinical project is evaluating voltage-dependent calcium channel ligands as potential medications using outpatient maintenance procedures to determine pharmacotherapy effects on cannabis self-administration in the laboratory and in the natural environment. A series of past studies used human drug-discrimination procedures to identify non-cannabinoid neurotransmitter systems involved in the abuse-related effects of THC. Another ongoing project is determining the ability of non-invasive electrical brain stimulation to offset cognitive impairment associated with cannabis intoxication. A second active area of research for Dr. Lile is the development of pharmacotherapies for the treatment of stimulant use disorders and understanding mechanisms of stimulant reinforcement, and he is collaborating on several human laboratory studies and clinical trials to this end. He is also the PI on a multi-site project that has established and validated intravenous cocaine self-administration procedures in humans and laboratory animals, which is now being adapted for use in a neuroimaging environment in order to study neurobehavioral mechanisms of drug choice within a reinforcement-learning framework. In addition to these research activities, Dr. Lile has been engaged in graduate education and mentoring early career scientists.  He is the primary mentor for two Ph.D. students in the UK Clinical and Translational Science program and a post-doctoral fellow. He is also the co-director of a course on Methods and Technologies in Clinical and Translational Science. Lastly, he has continued his service as a regular member of the UK Institutional Review Board.

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ISGIDAR CPDD Meeting 2019

June 15th, 2019
21 days to go.


The mission of ISGIDAR is to promote interest in, and to facilitate the dissemination of, new information related to drugs as reinforcers, especially as it may relate to human drug abuse.
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